Notice of Compliance with Conditions: A Policy in Limbo

Notice of compliance with conditions: a policy in limbo.

Since 1998, the Therapeutic Products Directorate (TPD) has had a policy termed the Notice of Compliance with conditions (NOC/c) in order to allow earlier marketing of promising drugs for serious conditions before the drugs have definitively demonstrated clinical efficacy. Drugs approved under the NOC/c must undergo post-marketing trials to show clinical benefits. The reasons that some drugs rec...

NOTICE IN COMPLIANCE WITH PUBLISHER POLICY: An edited version

[1] The influence of reduced dimensionality (two-dimensional (2-D) versus 3-D) on predictions of dense nonaqueous phase liquid (DNAPL) infiltration and entrapment in statistically homogeneous, nonuniform permeability fields was investigated using the University of Texas Chemical Compositional Simulator (UTCHEM), a 3-D numerical multiphase simulator. Hysteretic capillary pressure–saturation and ...

Biofuels Policy in Limbo

Philip Martin....................................9 Any game works better when the rules are enforced consis­ tently, whether it is the Superbowl or Monopoly around the kitchen table. If the referee is indecisive, then the players are uncertain about how to play and the game degenerates. Transportation fuel markets in the United States currently resemble a game with inconsistently enforced rules...

Aging Ergonomics: A Field with Inadequate Notice

prevalence of atopic dermatitis in children with type 1 diabetes mellitus in southeastern of iran (kerman province): a case-control study

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